Letter | Published:

Esterase Activity of Pepsin

Nature volume 204, page 580 (07 November 1964) | Download Citation

Subjects

Abstract

IT is known that many proteolytic enzymes—trypsin, chymotrypsin, thrombin, papain and others—hydrolyse peptide, amide and ester bonds. Pepsin, however, is generally believed to hydrolyse the peptide bonds only, without exhibiting the esterase activity1. This conclusion is based on observations which suggest that pepsin does not hydrolyse the ester bonds in several esters of N-substituted amino-acids and peptides, but no special investigation of the esterase activity of pepsin has been published.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , The Enzymes, edit. by Boyer, P., Lardy, H., and Myrback, K., 4, 63 (Academic Press Inc., New York-London, 1960).

  2. 2.

    , in Modern Problems of Biochemistry, edit. by Orekhovich, V. N., 2, 54 (Moscow, 1962).

  3. 3.

    , J. Biol. Chem., 180, 249 (1949).

  4. 4.

    , , and , Arch. Biochem. Biophys., 97, 219 (1962).

  5. 5.

    , , , and , Doklady AN U.S.S.R., 146, 945 (1962).

  6. 6.

    , , , and , Biochem. J., 73, 33 (1959).

  7. 7.

    , , and , Proc. Nat. Acad. Sci., 47, 759 (1961).

Download references

Author information

Affiliations

  1. Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the U.S.S.R., Moscow.

    • L. A. LOKSHINA
    • , V. N. OREKHOVICH
    •  & V. A. SKLYANKINA

Authors

  1. Search for L. A. LOKSHINA in:

  2. Search for V. N. OREKHOVICH in:

  3. Search for V. A. SKLYANKINA in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/204580a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.