Abstract
INJECTION of osmotically effective solutes in hypertonic solution causes nephrectomized rats to drink enough water to dilute the injected solute to isotonicity, so long as the initial increase in osmotic pressure does not exceed about 15 per cent1. With intact kidneys, however, less water is drunk because the solute can be eliminated in hypertonic urine, though the degree of hypertonicity depends on the rate of urine flow2. If drinking water is withheld excretion is even more rapid.
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References
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FITZSIMONS, J. Drinking caused by Constriction of the Inferior Vena Cava in the Rat. Nature 204, 479–480 (1964). https://doi.org/10.1038/204479a0
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DOI: https://doi.org/10.1038/204479a0
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