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Potassium-free Effect in Squid Axons

Abstract

PREVIOUS work1 has shown that the sodium efflux from squid giant axons is sensitive to the external concentration of potassium ions; the Na efflux falls to about 1/3 of control values when the sea water surrounding the axon is made free from potassium. Similar observations have been made with frog sartorius muscle2, but these showed further that when [Na]i in muscle was low, Na efflux was no longer sensitive to external [K]. The following experiments were undertaken to see if the Na efflux from squid axons would be similarly insensitive to [K0] if [Na]i were low.

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References

  1. Hodgkin, A. L., and Keynes, R. D., J. Physiol., 128, 28 (1955).

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  2. Keynes, R. D., and Swan, R. C., J. Physiol., 147, 591 (1959).

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  3. Mullins, L. J., Adelman, W. J., and Sjodin, R. A., Biophys. J., 2, 257 (1962).

    Article  CAS  Google Scholar 

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FRUMENTO, A., MULLINS, L. Potassium-free Effect in Squid Axons. Nature 204, 1312–1313 (1964). https://doi.org/10.1038/2041312b0

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