Abstract
FREESE has shown in a series of papers1–3 that most mutants induced by 5-bromouracil or 5-bromodeoxy-uridine in bacteriophage T4 can be induced to back-mutate by these same base analogues. This important observation led him to propose as one type of mutation the substitution of a G-C pair in the DNA for an A-T pair by a mechanism that necessarily could work in reverse. We have carried out similar experiments in the course of a study of the mutagenic action of nucleotide base analogues in Salmonella typhimurium and the results are somewhat different from those obtained with the bacteriophage.
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References
Benzer, S., and Freese, E., Proc. U.S. Nat. Acad. Sci., 44, 112 (1958).
Freese, E., J. Mol. Biol., 1, 87 (1959).
Freese, E., Proc. U.S. Nat. Acad. Sci., 45, 622 (1959).
Lederberg, J., and Zinder, N., J. Amer. Chem. Soc., 70, 4267 (1948).
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DAWSON, G., McMAHON, P. Mutants of Salmonella typhimurium induced by 5-Bromodeoxyuridine. Nature 204, 1226–1227 (1964). https://doi.org/10.1038/2041226a0
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DOI: https://doi.org/10.1038/2041226a0
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