Abstract
IN previous papers we have directed attention to the enhancement of imipramine mortality in mice by hyper-thyroidism and its diminution by propylthiouracil pre-treatment1,2. One of the major metabolites of imipramine is its demethylated product, desmethylimipramine (DMI)3, and this compound is said to be responsible for the antidepressant effect of the drug4,5. DMI is more potent than imipramine in antagonizing reserpine sedation in rats4 and in potentiating the reaction of cat nictitating membrane to norepinephrine6. For these reasons it seemed of interest to ascertain the effect of thyroid status on DMI mortality according to the previous technique.
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References
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Prange, A. J. (unpublished results).
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PRANGE, A., LIPTON, M. & LOVE, G. Effect of Altered Thyroid Status on Desmethylimipramine Mortality in Mice. Nature 204, 1204–1205 (1964). https://doi.org/10.1038/2041204a0
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DOI: https://doi.org/10.1038/2041204a0
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