Abstract
IN a previous publication1 we have reported that chlor-amphenicol inhibits hæmoglobin synthesis in human bone-marrow culture. Erslev and Iossifides2 found that not only chloramphenicol but also tetracycline and erythromycin had similar effects on immature erythrocytes in vitro. Because tetracycline and erythromycin do not cause toxic hæmatological reactions in man, this finding would seriously limit the validity of applying this in vitro method to the study of the effect of chloramphenicol on erythroid cells in vivo. It seemed important, therefore, to extend our experiments and to study the effect of tetracycline and erythromycin on hæmoglobin synthesis in human bone-marrow cultures, using the same methods as were used to study the effect of chloramphenicol.
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References
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VAS, M., BAIN, B. & LOWENSTEIN, L. Effects of Erythromycin and Tetracycline in Human Bone-marrow Cultures. Nature 204, 1100–1101 (1964). https://doi.org/10.1038/2041100a0
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DOI: https://doi.org/10.1038/2041100a0
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