Abstract
THE ratio of acid secretion by gastric mucosa to the oxygen uptake involved in the secretory process does not seem to have a value significantly greater than four3,4 as predicted by the redox theory of acid secretion2,6. Forte and Davies5 have recently reported a series of experiments on electrically short-circuited gastric mucosæ of the bullfrog, in which thiocyanate produced a decrease in oxygen uptake and acid secretion. The ratio ΔqH+/ΔqO2 (qH+ = rate of acid secretion, qO2 = rate of oxygen uptake in the same units) was calculated from the mean rates of acid secretion and oxygen uptake before and after thiocyanate in each experiment. This ratio had high mean values which varied inversely with the concentration of thiocyanate from 5.1 to 12.0.
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References
Bannister, W. H., Biochem. J., 89, 62P (1963).
Conway, E. J., and Brady, T. G., Nature, 162, 456 (1948).
Davenport, H. W., Fed. Proc., 11, 715 (1952).
Davenport, H. W., and Chavre, V. J., Amer. J. Physiol., 174, 203 (1953).
Forte, J. G., and Davies, R. E., Amer. J. Physiol., 206, 218 (1964).
Robertson, R. N., Biol. Rev., 35, 231 (1960).
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BANNISTER, W. Effect of Thiocyanate on Secretion of Acid and Uptake of Oxygen by Gastric Mucosa of the Frog. Nature 203, 978–979 (1964). https://doi.org/10.1038/203978a0
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DOI: https://doi.org/10.1038/203978a0
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