Abstract
PREVIOUS investigations1,2 established the essential requirements of Pasteurella tularensis (P. tularensis) for growth in both complex and chemically defined media. However, the media described sustained luxurious growth of P. tularensis when relatively large numbers of cells (about 106 to 5 × 106/ml. medium) were used for inoculation. Attempts to reduce the size of the inoculum by supplementing the media with a variety of vitamins, tissue extracts and other preparations noted for their growth-promoting ability, were by and large unsuccessful. The nutritional fastidiousness of P. tularensis appeared particularly puzzling in view of the notoriously extreme infectivity of this micro-organism, which is reputed to be capable of multiplying in vivo out of a few cells3. Furthermore, both highly virulent and completely avirulent strains exhibited the same pattern of growth requirements.
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References
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Halman, M., and Mager, J. (to be published).
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MAGER, J. A Factor required for Growth Initiation of Pasteurella tularensis. Nature 203, 898 (1964). https://doi.org/10.1038/203898a0
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DOI: https://doi.org/10.1038/203898a0
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