Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effect of Alkylating Agents and Whole-body X-irradiation on Thymus

Nature volume 203, pages 891–892 (1964)Cite this article

Abstract

MANY investigations have indicated the disruption of the structure of DNA or nucleohistone by nitrogen mustards or ionizing irradiation1,2. The labilization of nucleohistone from thymus after irradiation has been measured by Hagen3 by increased extraction of DNA by phenol treatment. Cole and Ellis4 have reported an increase in soluble polynucleotide in spleen after irradiation. In investigations on the effects of these agents on amino-acid incorporation in thymus nuclei and cytoplasmic microsomal and 5.1P fractions5, the presence of acid insoluble DNA material in the various fractions became apparent. The finding is reported primarily because of its importance in interpreting results of changes in enzyme activities in cell fractions from radio-sensitive tissues after treatment.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ross, W. C. J., Biological Alkylating Agents (Butterworths, London, 1962).

    Google Scholar 

  2. Ord, M. G., and Stocken, L. A., The Biochemical Lesion in Vivo and in Vitro in Mechanisms in Radiobiology, 1 (Academic Press, 1961).

    Google Scholar 

  3. Hagen, U., Nature, 18, 187, 1123 (1960).

    Google Scholar 

  4. Cole, L. J., and Ellis, M. E., Rad. Res., 7, 508 (1957).

    Article  CAS  Google Scholar 

  5. Herranen, A., Fed. Proc., 21, 424 (1962).

    Google Scholar 

  6. Allfrey, V. G., Mirsky, A. E., and Osawa, S., J. Gen. Physiol., 40, 451 (1957).

    Article  CAS  Google Scholar 

  7. Webb, J. M., and Levy, H. B., J. Biol. Chem., 213, 107 (1955).

    CAS  PubMed  Google Scholar 

  8. Whitfield, J. F., and Rixon, R. H., Exp. Cell Res., 31, 140 (1963).

    Article  CAS  Google Scholar 

  9. Peacocke, A. R., and Preston, B. N., Nature, 192, 228 (1961). Lloyd, P. H., and Peacocke, A. R., Nature, 200, 428 (1963).

    Article  ADS  CAS  Google Scholar 

  10. Brookes, P., and Lawley, P. D., Exp. Cell Res., Supp. 9, 521 (1963).

  11. Biesele, J. J., Exp. Cell Res., Supp. 9, 525 (1963).

Download references

Author information

Authors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Mass.

    AILENE HERRANEN

Authors
  1. AILENE HERRANEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HERRANEN, A. Effect of Alkylating Agents and Whole-body X-irradiation on Thymus. Nature 203, 891–892 (1964). https://doi.org/10.1038/203891a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/203891a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing