Abstract
CYTOPLASMIC inclusions containing RNA have been noted in HeLa cells treated with puromycin1, an anti-metabolite which is a selective inhibitor of protein synthesis2,3. It is now clear that these inclusions appear in a large proportion of treated cells when high concentrations of puromycin are used, and that these structures bear a resemblance to nucleoli as regards morphological appearances and their dependence on continued synthesis of cellular RNA.
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STUDZINSKI, G. Nucleolus-like Inclusions in the Cytoplasm of HeLa Cells treated with Puromycin. Nature 203, 883–884 (1964). https://doi.org/10.1038/203883a0
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DOI: https://doi.org/10.1038/203883a0
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