Abstract
FOR an understanding of the pathogenesis of pathological processes, the initial stages of their development are usually most important. At first only the direct sequelæ of the causal agent play a part, and the position is not very complicated by regulatory and reparative processes aiming at the renewal of the normal state. The morphology of early stages of the hypersensitivity reaction of the delayed type has been examined by several authors1–4, who directed attention mainly to the composition of the cell infiltrate. Because inflammatory infiltration is a result of tissue damage, I was interested rather in changes in tissues where the immunological reaction takes place.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gell, P. G. H., in Cellular and Humoral Aspects of the Hypersensitive States, edit. by Lawrence, H. S., 43 (Hoeber-Harper, New York, 1959).
Waksman, B. H., in Ciba Found. Symp. Cellular Aspects of Immun., 280 (J. and A. Churchill, London, 1960).
Kaplan, M. H., and Dines, L., in Henry Ford Hospital Intern. Symp. Mechanisms of Hypersensitivity, 449 (Little, Brown and Co., Boston–Toronto, 1959).
Boughton, B., and Spector, W. G., J. Path. Bact., 85, 371 (1963).
Waksman, B. H., Amer. J. Path., 37, 673 (1960).
Waksman, B. H., and Adams, R. D., Amer. J. Path., 41, 135 (1962).
Goldberg, B., Kantor, F. S., and Benacerraf, B., Brit. J. Exp. Path., 43, 621 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KOLÍN, A. Early Regressive Changes during the Tuberculin Skin Reaction. Nature 203, 882–883 (1964). https://doi.org/10.1038/203882b0
Issue Date:
DOI: https://doi.org/10.1038/203882b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.