Abstract
IT has been shown1 that iproniazid increased the hypertensive effects of indirect sympathomimetic amines, without altering significantly those of the directly acting catecholamines. We suggested later2 that monoaminoxidase inhibitors could facilitate the release of catecholamines induced by indirectly acting sympathomimetic amines. In this communication it is reported that two Harmala alkaloids, harmaline and harmine, which are both monoaminoxidase inhibitors with a rapid and brief action, can release catecholamines under certain conditions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schmitt, H., and Gonnard, P., Arch. int. Pharmacod., 108, 74 (1956).
Schmitt, H., and Schmitt, H., Arch. int. Pharmacod., 132, 97 (1961).
Shipley, J. A., and Tilden, J. N., Proc. Soc. Exp. Biol. Med., 64, 453 (1947).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHMITT, H., SCHMITT, H. Interrelationships between Amphetamine and Harmala Alkaloids. Nature 203, 878–879 (1964). https://doi.org/10.1038/203878a0
Issue Date:
DOI: https://doi.org/10.1038/203878a0
This article is cited by
-
Psychotropic activity and antimonoamine oxidase action of 1-thiolactim ethers of 3-carboline
Pharmaceutical Chemistry Journal (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
