Abstract
FORMATION of lymphoid follicles with light germinal centres is generally considered as being characteristic of myasthenia gravis1 and is regarded as one of the manifestations of the auto-immune nature of this disease2. However, quite similar changes are induced in the thymus with no symptoms of myasthenia by subcutaneous injection of Freund's adjuvant3 or through direct administration to the thymus of various antigens4, proving only that the thymus is involved in every enhanced immunization process. On the other hand, the relationship of myasthenia gravis to thymus pathology is beyond any doubt; yet the nature of this relationship is obscure.
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References
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Svet-Moldavsky, G. J., Ravkina, L. I., and Spektor, N. U., Vestnick Akademii Meditsynskich Nauk S.S.S.R., No. 6, 69 (1964) (in Russian).
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SVET-MOLDAVSKY, G., SPECTOR, N. & RAVKINA, L. Experimental Myopathic Syndrome associated with Pituitary Activation of Thymus. Nature 203, 771–772 (1964). https://doi.org/10.1038/203771a0
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DOI: https://doi.org/10.1038/203771a0
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