Abstract
THE presence of a substance in the G.2 fraction of human blood plasma with a slow contracting activity on plain muscle (S.M.C.) was established and the active principle has been isolated from the G.2 fraction and designated as G acid1. It is important to note that the same effect has been obtained from citrated human plasma and is best observed with dialysed plasma, since dialysis eliminates the quick contracting agents2. The chemical nature of G acid prompted a search for a possible precursor of this lipid-soluble unsaturated fatty acid (3-octadecenoic acid)1.
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Gabr, Y., Brit. J. Pharm. Chem., 11, 93 (1956).
Schachter, M., J. Physiol., 129, Proc. 30 (1955).
Vogt, W., J. Physiol., 136, 131 (1956).
Phillips, G. B., Biochim. Biophys. Acta, 29, 594 (1958).
Kekwick, R. A., and Mackay, M. E., Med. Res. Counc. Spec. Rep. Ser. No. 286 (H.M.S.O., London, 1954).
Gabr, Y., and Aly, R. H., Nature, 183, 897 (1959).
Gabr, Y., Brit. J. Pharm. Chem., 17, 51 (1961).
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GABR, Y. Possible Role of a Phospholipid in the Development of the Slow Muscle Contracting Activity of Human Plasma. Nature 203, 765 (1964). https://doi.org/10.1038/203765a0
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DOI: https://doi.org/10.1038/203765a0
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