Effect of Intraventricularly Injected Anticerebral Antibodies on the Histamine-like Substance and Potassium Content of Various Regions of the Brain of the Cat

Abstract

IN an attempt to investigate the possible differential reactivity of various cerebral structures when exposed to the action of different brain region anti-sera, it has been shown that the injection of heterologous anti-caudate nucleus antibody into the lateral cerebral ventricle of the cat was followed by pronounced electrographic abnormalities, confined mainly to the caudate nucleus. Since the electrical activity of other, simultaneously investigated brain regions was not essentially modified, the alterations observed were interpreted as being strongly suggestive of the possibility that the anti-caudate antibody has an affinity for the homologous nervous tissue¹.