Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Proliferation of Transferred Spleen Cells after Antigenic Challenge

Nature volume 203, pages 418–419 (1964)Cite this article

Abstract

THE transfer of immunologically competent cells to an immunologically inert recipient is a technique which has been useful in the examination of the antibody-forming capacity of the donor cells. Under these conditions, circulating antibody may be found in the recipient, if the antigenic stimulation is given to the donor prior to transfer, or to the recipient after transfer1,2. That the donor cells are responsible for the antibody found in the recipient is evident in that disruption of the donor cells eliminates the antibody response.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Chase, M. W., in The Nature and Significance of the Antibody Response, edit. by Pappenheimer, jun., A. M., 156 (New York: Columbia Univ. Press, 1953).

    Google Scholar 

  2. Makinodan, T., and Gengoyian, N., Radiation Protection and Recovery, edit. by Hollaender, Alexander, 316 (Pergamon Press, New York and London, 1960).

    Book  Google Scholar 

  3. Harris, S., Harris, T. W., and Farber, M. G., J. Immunol., 72, 148 (1954).

    Google Scholar 

  4. Baney, R. N., Vazquez, J. J., and Dixon, F. J., Proc. Soc. Exp. Biol and Med., 109, 1 (1962).

    Article  CAS  Google Scholar 

  5. Hughes, W. L., Bond, V. P., Beecher, G., Cronkite, E. P., Painter, R. B., Quastler, H., and Sherman, F. G., Proc. U.S. Nat. Acad. Sci., 44, 476 (1958).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. EDWARD P. COHEN: Career Research Development awardee of the U.S. Public Health Service.

Authors and Affiliations

  1. Department of Medicine, University of Colorado Medical Center, Denver, Colorado

    MARTIN J. COHEN & EDWARD P. COHEN

Authors
  1. MARTIN J. COHEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. EDWARD P. COHEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

COHEN, M., COHEN, E. Proliferation of Transferred Spleen Cells after Antigenic Challenge. Nature 203, 418–419 (1964). https://doi.org/10.1038/203418a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/203418a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing