Abstract
EVIDENCE has been obtained recently that 7Sγ-globulin and myeloma proteins can be divided into three types on the basis of antigenic characteristics as well as other differences in the H chains1–3. A variety of antisera in rabbits to individual myeloma proteins as well as monkey antisera to H chains have served to bring out these variations. Splitting of γ-globulin with papain has also brought out differences in these three types2. Since the determinants involved in the Gm system have been localized to the H chains4,5, it was thought of interest to test γ-globulins of the three types for the various factors involved in the Gm system. For this purpose, myeloma proteins of the three types were utilized6,7. Also included were investigations of the newly described Gm(f) factor8, which has been found in the majority of myeloma proteins which were previously found to be negative for the Gm(a) and Gm(b) factors9. Striking differences in the distribution of the Gm factors were encountered for the proteins of each type.
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References
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KUNKEL, H., ALLEN, J., GREY, H. et al. A Relationship between the H Chain Groups of 7S Γ-Globulin and the Gm System. Nature 203, 413–414 (1964). https://doi.org/10.1038/203413a0
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DOI: https://doi.org/10.1038/203413a0
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