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Mutagenic Action of Hyponitrous Acid and Glucose Oxime

Abstract

ONE of us has demonstrated1–5 with his co-workers that hydroxylamine, nitrous acid, hydrogen peroxide, hypo-nitrous acid and oxime can induce viral nuclear poly-hedrosis in healthy silkworms. Among these, the mutagenic action of the first-mentioned three substances has recently been proved by Freese6, Gierer7 and Wyss8. We have now found that acidified hyponitrite and glucosoxime produce a mutation in a bacteriophage.

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YAMAFUJI, K., WATANABE, K. Mutagenic Action of Hyponitrous Acid and Glucose Oxime. Nature 203, 409–410 (1964). https://doi.org/10.1038/203409a0

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