Abstract
INCORPORATION of the alkylsulphonamido group into the benzene ring of phenethanolamines provides a series of compounds which possess the intensity of action and biological profile of the phenolic phenethanolamines. In addition, some members of the series are effective antagonists to the actions of the catecholamines. It would appear that, at the several adrenergic receptor sites, the alkylsulphonamido group can effect the same events as the phenolic hydroxyl group.
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References
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LARSEN, A., LISH, P. A New Bio-isostere : Alkylsulphonamidophenethanolamines. Nature 203, 1283–1284 (1964). https://doi.org/10.1038/2031283a0
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DOI: https://doi.org/10.1038/2031283a0
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