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Formation of 5-Hydroxytryptophol from Endogenous 5-Hydroxytryptamine by Isolated Blood Platelets

Nature volume 203, pages 1281–1283 (1964)Cite this article

Abstract

IN addition to 5-hydroxytryptamine (5HT) and 5-hydroxyindolacetic acid, a neutral metabolite of 5HT could be demonstrated in the incubation medium of isolated platelets of the rabbit by paper and thin-layer chromatography. This metabolite develops the typical green-yellow fluorescence of 5-hydroxyindolyl compounds in short-wave ultra-violet light if acidified with 4 N hydrochloric acid. With Folin–Denis reagent it shows the blue colour characteristic for phenols1.

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Authors and Affiliations

  1. Research Department, F. Hoffman-La Roche and Co. Ltd., Basle, Switzerland

    G. BARTHOLINI, A. PLETSCHER & H. BRUDERER

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  1. G. BARTHOLINI
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  2. A. PLETSCHER
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  3. H. BRUDERER
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BARTHOLINI, G., PLETSCHER, A. & BRUDERER, H. Formation of 5-Hydroxytryptophol from Endogenous 5-Hydroxytryptamine by Isolated Blood Platelets. Nature 203, 1281–1283 (1964). https://doi.org/10.1038/2031281b0

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