Abstract
IT has been shown that many of the tumours induced in rats by the oral administration of 9,10-dimethyl-1,2-benzanthracene (DMBA) stop growing and some undergo spontaneous regression1,2. It has also been shown that DMBA produces massive adrenocortical necrosis when given in doses which would ultimately give rise to tumours3. It appeared possible that spontaneous regression might be due to adrenocortical insufficiency which permitted the development of an immunological mechanism. This communication reports experiments designed to test this hypothesis.
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References
Young, S., Cowan, D. M., and Sutherland, L. E., J. Path. Bact., 85, 331 (1963).
Young, S., and Cowan, D. M., Brit. J. Cancer, 17, 85 (1963).
Huggins, C., and Morii, S., J. Exp. Med., 114, 741 (1961).
Ingle, D. J., personal communication.
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YOUNG, S., HELFENSTEIN, J. & BAKER, R. Relationship of Adrenocortical Insufficiency to Spontaneous Regression in Mammary Tumours induced in Rats by Oral Administration of Dimethylbenzanthracene. Nature 203, 1079–1080 (1964). https://doi.org/10.1038/2031079a0
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DOI: https://doi.org/10.1038/2031079a0
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