Abstract
L-CYSTEINE, in common with several other amino-acids, is able to inhibit the uptake of L-histidine by brain slices, but the inhibition which it produces, unlike that produced by the other amino-acids, is non-competitive1. It therefore appeared possible that cysteine might also have an inhibitory action on other transport phenomena. Its effect on the transport system for potassium, as indicated by alteration in the level of potassium in brain slices (normally maintained well above that of a suitable environment2), has therefore been investigated, and compared with the effect of other amino-acids.
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Neame, K. D., J. Neurochem., 11, 67 (1964).
Pappius, H. M., and Elliott, K. A. C., Canad. J. Biochem. Physiol., 34, 1053 (1956).
Neame, K. D., J. Neurochem., 6, 358 (1961).
Terner, C., Eggleston, L. V., and Krebs, H. A., Biochem. J., 47, 139 (1950).
Riggs, T. R., Walker, L. M., and Christensen, H. N., J. Biol. Chem., 233, 1479 (1958).
Dent, C. E. (personal communication).
Eaton, M. D., and Scala, A. R., Exp. Cell Res., 33, 481 (1964).
Emmelot, P., Mizrahi, I. J., Naccarato, R., and Benedetti, E. L., J. Cell Biol., 12, 177 (1962).
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NEAME, K. L-Cysteine as Inhibitor of Potassium Retention by Brain Slices. Nature 203, 1067 (1964). https://doi.org/10.1038/2031067a0
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DOI: https://doi.org/10.1038/2031067a0
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