Abstract
INHERITED antigenic differences in human sera have been revealed by means of a gel-diffusion technique in which certain, but not all, human sera formed precipitates with serum from a repeatedly transfused patient (C. de B.)1–4. The new, genetically determined serum system was called the Ag-system and the two main types of human sera revealed by the antiserum C. de B. were called Ag(a+) (reactors) and Ag(a−) (non-reactors). In addition, more than 20 different antisera revealing at least five and possibly seven different antigenic specificities on the beta lipoproteins have been found5,6. The use of the designation ‘Lpa’ for the lipoprotein polymorphism has also been suggested5.
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HIRSCHFELD, J., BLUMBERG, B. & ALLISON, A. Relationship of Human Anti-lipoprotein Allotypic Sera. Nature 202, 706–707 (1964). https://doi.org/10.1038/202706a0
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DOI: https://doi.org/10.1038/202706a0
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