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Catalase Activity in the Epidermis of Patients with Advanced Cancer

Nature volume 202, pages 203–204 (1964)Cite this article

Abstract

HUMAN liver catalase is depressed in patients with advanced cancer. Clinical improvement may cause a rise in liver catalase1. An investigation was, therefore, undertaken to determine whether skin catalase was subject to the same variations. As depression of human liver catalase has been shown to be related to loss in weight2, attention was directed to this aspect of the problem. Determinations were performed before and during cancer chemotherapy with the following cytostatics: 5-fluoroura-cil (5FU), cyclophosphamide, SPG827 (benzylidene compounds of the glucosides of Podophyllum emodi), SPI 77 (ethyl hydrazide of podophyllic acid) and 6W54 (ethyl-N-N-bis (2-chloropropyl) carbamate). This forms part of work on skin changes occurring during cancer chemotherapy3–5.

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Authors and Affiliations

  1. Department of Radiotherapy, Pretoria General Hospital, and University of Pretoria, South Africa

    GEOFFREY FALKSON & M. E. de JAGER

Authors
  1. GEOFFREY FALKSON
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  2. M. E. de JAGER
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FALKSON, G., de JAGER, M. Catalase Activity in the Epidermis of Patients with Advanced Cancer. Nature 202, 203–204 (1964). https://doi.org/10.1038/202203a0

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