Abstract
SEVERAL hypocholesterolemic drugs uncouple oxidative phosphorylation in rat liver mitochondria1. Also some of these drugs, for example, benzmalecene and triparanol (‘MER-29’), inhibit multiplication of Ochromonas danica, a phytoflagellate; oleic acid annuls this inhibition, but sterols or sterol precursors do not2. Do these drugs inhibit synthesis of ATP in O. danica ? It remains to be seen if there is an especially close relation between ATP synthesis and lipid synthesis.
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AARONSON, S. Inhibition of Respiration in a Flagellate Protozoon by Hypocholesterolemic Drugs. Nature 202, 1355 (1964). https://doi.org/10.1038/2021355a0
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DOI: https://doi.org/10.1038/2021355a0
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