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Detection of Secobarbital Metabolite in the Urine of the Rat


THE metabolic products of secobarbital were identified in dog's urine by Waddell1 and in human urine by Cochin and Daly2. In this investigation two extra absorbing spots were observed in the extract of urine from rat receiving secobarbital. So it was thought worth while to report this as one of the two spots which had the same RF value to that of a metabolite of secobarbital.

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  1. Waddell, W. J., Fed. Proc. 21, 182 (1962); 22, 480 (1963).

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  2. Cochin, J., and Daly, J. W., J. Pharmacol. Exp. Ther., 139, 154 (1963).

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NIYOGI, S. Detection of Secobarbital Metabolite in the Urine of the Rat. Nature 202, 1225–1226 (1964).

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