THE role of macromolecules in cell cultures remains obscure. For this reason tissue culture media are supplemented with serum or with purified protein fractions. In some instances other macromolecules, for example, carboxymethyl cellulose, are used1.
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MICHL, J. Probable Function of Macromolecules in Tissue Culture. Nature 202, 1133–1134 (1964). https://doi.org/10.1038/2021133b0
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