IT has been suggested on several grounds1–5 that, in the striated muscle fibres of frogs, some part of the ‘triads’6 of the sarcoplasmic reticulum (presumably the middle element) is in some degree continuous with the external fluid as regards conduction of electricity and diffusion of electrolytes. No continuity of this kind has yet been seen in electron micrographs, but the possibility remains that ions may be able to enter and leave the tubules through pores too small to be detected with the electron microscope or that openings that exist in the living state may be obliterated during fixation and other preparatory procedures for electron microscopy.
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ENDO, M. Entry of a Dye into the Sarcotubular System of Muscle. Nature 202, 1115–1116 (1964). https://doi.org/10.1038/2021115b0
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