Abstract
BOTH the site and mechanism of action of erythropoietin (ESF) remain to be elucidated. Some investigators have stated that ESF acts exclusively on the hæmocytoblast or stem cell, with the resulting production of increased numbers of erythrocytic cells1,2; others have presented evidence that ESF also may act on red blood cells that have advanced beyond the stem cell stage3–6. We have performed experiments to assess the ability of whole bones to incorporate radio-iron in vitro. Various ESF preparations extracted from rabbit plasma caused significant increases in iron-59 uptake in such bones; but similar effects were not observed with a more purified extract obtained from sheep plasma.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Alpen, E. L., and Cranmore, D., The Kinetics of Cellular Proliferation, edit. by Stohlman, jun., F., 290 (Grune and Stratton, Inc., New York, 1959).
Erslev, A. J., Blood, 14, 386 (1959).
Linman, J. W., and Bethell, F. H., Factors Controlling Erythropoiesis, 82 (C C Thomas, Springfield, Ill., 1960).
Stohlman, jun., F., The Kinetics of Cellular Proliferation, edit. by Stohlman, jun., F., 327 (Grune and Stratton, Inc., New York, 1959).
Gordon, A. S., Lobue, J., Dornfest, B. S., and Cooper, G. W., in Erythropoiesis, edit. by Jacobson, L. O., and Doyle, M., 321 (Grune and Stratton, Inc., New York, 1962).
Fruhman, G. J., and Fischer, S., Experientia, 18, 462 (1962).
Hodgson, G., Fischer, S., Peretta, M., Eskuche, I., Araya, G., and Dina Marca, M., Blood, 16, 1398 (1960).
Fischer, S., Bruns, G. P., Lowy, B. A., and London, I. M., Proc. U.S. Nat. Acad. Sci., 49, 219 (1963).
Past, W. L., Amer. J. Path., 39, 443 (1961).
Past, W. L., Amer. J. Path., 42, 285 (1963).
Perretta, M. A., and Thomson, R. Y., Nature, 190, 912 (1961).
Dukes, P. D., and Goldwasser, E., Nature, 195, 1222 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FISCHER, S., FRUHMAN, G. Effect of an Erythropoietin Preparation on Uptake of Iron-59 by Tibiæ of New-born Rats. Nature 201, 836–838 (1964). https://doi.org/10.1038/201836a0
Issue Date:
DOI: https://doi.org/10.1038/201836a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
