Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Activity of Aspartate Transcarbamylase in Heart and Liver of the Developing Rat

Nature volume 201, pages 616–617 (1964)Cite this article

Abstract

ASPARTATE transcarbamylase (ATC) catalyses transfer of the carbamyl group from carbamyl phosphate to L-aspartate yielding carbamyl aspartate. This reaction is the first step peculiar to de novo synthesis of pyrimidine bases. Lowenstein and Cohen1 described the distribution of ATCin tissues of the adult rat. Activity was high in liver, intestine, stomach, testis, kidney, lung, brain, and spleen; muscle contained less activity and there was negligible activity in blood and heart.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lowenstein, J. S., and Cohen, P. P., J. Biol. Chem., 220, 57 (1956).

    CAS  PubMed  Google Scholar 

  2. Calva, E., and Cohen, P. P., Cancer Res., 19, 679 (1959).

    CAS  PubMed  Google Scholar 

  3. Kim, S., Ph.D. thesis, Univ. Wisconsin (1959).

  4. Koritz, S. B., and Cohen, P. P., J. Biol. Chem., 209, 145 (1954).

    CAS  PubMed  Google Scholar 

  5. Bresnick, E., Biochim. Biophys. Acta, 67, 425 (1963).

    Article  CAS  Google Scholar 

  6. Kennan, A. L., and Cohen, P. P., Develop. Biol., 1, 511 (1959).

    Article  Google Scholar 

  7. Hurwitz, R., and Kretchmer, N. (unpublished data).

  8. Bowers, M. D., and Grisolia, S., Comp. Biochem. Physiol., 5, 1 (1962).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. YVES NORDMANN

    Present address: Hôpital des Enfants Malades, 149 Rue de Sèvres, Paris, 15, France

  2. YVES NORDMANN: Post-doctoral Fellow, training grant, National Institutes of Health. Recipient of a Lederle International Award, Lederle Laboratories

Authors and Affiliations

  1. Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California

    YVES NORDMANN, RUTH HURWITZ & NORMAN KRETCHMER

Authors
  1. YVES NORDMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. RUTH HURWITZ
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. NORMAN KRETCHMER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

NORDMANN, Y., HURWITZ, R. & KRETCHMER, N. Activity of Aspartate Transcarbamylase in Heart and Liver of the Developing Rat. Nature 201, 616–617 (1964). https://doi.org/10.1038/201616a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/201616a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing