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Fluoroacetate and Cyanocobalamin Absorption in the Rat

Nature volume 201, pages 400–401 (1964)Cite this article

Abstract

IT has been shown in this laboratory that the administration of fluoroacetate to 3-month-old female rats of the Scott–Russ strain inhibits the absorption of cyanocobalamin1. This was done by tube-feeding each animal with 15 ng 58Co-labelled cyanocobalamin 2 h after it had received an intraperitoneal injection (80 µg/100 g body-wt.) of sodium fluoroacetate. Each animal was killed 24 h after feeding, and after removal of the stomach and intestines the radioactivity of the carcass was determined by dissolving it as completely as possible in strong nitric acid and counting in a scintillation counter.

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References

  1. Latner, A. L., and Hodson, A. W., Biochim. Biophys. Acta, 56, 185 (1962).

    Article  CAS  Google Scholar 

  2. Booth, C. C., Chanarin, I., Anderson, B. B., and Mollin, D. L., Brit. J. Hœmat., 3, 253 (1957).

    Article  CAS  Google Scholar 

  3. Latner, A. L., Green, C., and Raine, L., Biochem. J., 69, 60P (1958).

    Article  CAS  Google Scholar 

  4. Latner, A. L., Hodson, A. W., and Smith, P. A., Lancet, ii, 230 (1962).

  5. Gabbe, E. E., Heinrich, H. C., Bornholt, E., Heyde, K., Weist, D., in Second European Symp. Vitamin B12 and Intrinsic Factor, edit. by Heinrich, H. C., 116 (Ferdinand Enke, Stuttgart, 1962).

    Google Scholar 

  6. Herbert, V., Fed. Proc., 19, 884 (1960).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Chemistry, University and Royal Victoria Infirmary, Newcastle upon Tyne

    A. L. LATNER & A. W. HODSON

Authors
  1. A. L. LATNER
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  2. A. W. HODSON
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LATNER, A., HODSON, A. Fluoroacetate and Cyanocobalamin Absorption in the Rat. Nature 201, 400–401 (1964). https://doi.org/10.1038/201400a0

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