Abstract
ADENOSINE triphosphate (ATP) has been known for some time to inhibit or reverse the swelling of isolated rat liver mitochondria1–5. Contraction by ATP of sarcosomes from pigeon-breast muscle6 and from rat heart7 has also been reported. The results hitherto available suggested that the contraction of mitochondrial particles is unique to ATP, since triphosphates of other nucleotides were found to be ineffective4. As an outcome of investigations on the swelling-contraction characteristics of rat heart sarcosomes it has now been found that while diphospho-pyridine nucleotide (DPN) is a powerful inducer of particulate swelling8,9, the reduced nucleotide (DPNH) is as effective as ATP to contract swollen sarcosomes.
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ARCOS, J., WALDER, J. & ARGUS, M. Inhibition and Reversal of Swelling of Rat Heart Sarcosomes by Reduced Diphosphopyridine Nucleotide. Nature 201, 398–400 (1964). https://doi.org/10.1038/201398b0
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DOI: https://doi.org/10.1038/201398b0
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