Abstract
WE have already reported that several halogenated pyrimidines including 5-fluorodeoxyuridine (FUDR) did not show a complete inhibition of the multiplication of adeno type 1 virus in the experiments using the TCID50 estimating dilution method, while vaccinia virus was clearly inhibited with FUDR and some other halogenated pyrimidines1. On the contrary, Flanagan and Ginsberg2 and Green3 reported that FUDR showed clear inhibition during the early phase of the multiplication of adeno type 4 or type 2 viruses. Thus, the results previously described by us1 seemed inconsistent with those obtained by them2,3. If the sensitivity of adeno virus towards the inhibitory effect of FUDR is not so clear as vaccinia virus shows, it might be suggested that the metabolic pathway essential for the replication of adeno virus must be a different one from, the ways blocked by halogenated pyrimidines. To prove this point, the influence of FUDR on the single growth curve and the cell-infective unit of adeno type 1 virus was investigated.
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References
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SETO, Y., TOYOSHIMA, S. & UEDA, T. Influence of 5-Fluorodeoxyuridine on the Cell-infective Unit of Adeno Virus in HeLa Cells. Nature 201, 219–220 (1964). https://doi.org/10.1038/201219a0
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DOI: https://doi.org/10.1038/201219a0
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