Abstract
IN the course of a Brucella eradication programme in an adult vaccinated herd certain anomalies were noted in the immune responses of 6-months-old calves to Brucella abortus strain 19 vaccination. Calves were routinely tested for Brucella sero-agglutinins immediately prior to vaccination. A proportion of these calves had positive titles at this stage, and after vaccination a few of them showed no, or very little, rise in agglutinin titre. On checking the clinical status of the dams of such calves it was found that they were Brucella-infected animals. It seemed likely that these calves had been exposed to Brucella abortus at a very early age and often for a prolonged period. Therefore it was decided to set up a preliminary experiment to investigate the immune response of calves which had been experimentally exposed to virulent Brucella abortus during the early days of life.
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HIGNETT, P., NAGY, L. Effect of Exposure of Very Young Calves to Virulent Brucella abortus on their Serological Response to Re-infection by the same Organism at 6 Months of Age. Nature 201, 204 (1964). https://doi.org/10.1038/201204a0
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DOI: https://doi.org/10.1038/201204a0
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