Abstract
INVESTIGATIONS of immediate-type active cutaneous hypersensitive reactions in mice1 led to the conclusion that the characteristic reaction consisted of two distinct phases. A rapid phase (phase 1), consisting of an immediate œdematous response, could be detected within 6–9 days of a single sensitizing injection of egg albumen in adjuvant. It continued to occur, at least transiently, throughout the period of testing (36 days after sensitization). A slower phase (phase 2) was first noticed approximately 12 days after sensitization. At first phase 2 developed 2–3 h after the animals had been skin-tested; but as the time interval between sensitization and challenge increased it appeared more rapidly. Fully developed phase 2 reactions were macroscopically and microscopically typical Arthus reactions.
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References
McCamish, J., and Benedict, A. A., J. Immunol., 91 (1963).
Kabat, E. A., and Mayer, M. M., Experimental Immunochemistry (Thomas, Springfield, 1961).
Peterson, E. A., and Sober, H. A., J. Amer. Chem. Soc., 78, 751 (1956).
Ovary, Z., Intern. Arch. Allergy, 3, 162 (1952).
Benedict, A. A., Brown, R. J., and Ayengar, R., J. Exp. Med., 115, 195 (1962).
Gozsy, B., and Kato, L., Ann. N.Y. Acad. Sci., 88 (1), 43 (1960).
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MCCAMISH, J., BOYDEN, M. & BENEDICT, A. Immediate Cutaneous Hypersensitivity in Mice: in vitro and in vivo Characteristics of Serum from Hypersensitive Mice. Nature 201, 203–204 (1964). https://doi.org/10.1038/201203a0
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DOI: https://doi.org/10.1038/201203a0
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