Abstract
THE local humoral and cellular events which occur in the skin following cell injury are very similar to those which follow the intradermal injection of soluble antigen in an immunized animal which has antibodies in its circulation. In both cases there is an immediate increase in the permeability of the small blood vessels, adherence of leucocytes to the vessel walls and migration of leucocytes into the surrounding tissue1–3. The usual explanation of this similarity is that the antibody–antigen reaction causes a certain degree of cell damage, with consequent release of the pharmacologically active substances which are also liberated following injury to cells from other causes. In this communication an alternative, and in fact opposite, view is put forward. It is suggested that the reaction due to cell injury is similar to that due to antibody–antigen interaction because damage to cells causes the local formation of antibody–antigen complexes.
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BOYDEN, S. Autoimmunity and Inflammation. Nature 201, 200–201 (1964). https://doi.org/10.1038/201200a0
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DOI: https://doi.org/10.1038/201200a0
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