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Amino-acid Content of Antispermatogenic Antigen

Nature volume 201, pages 197–198 (1964)Cite this article

Abstract

A SINGLE injection of homologous testicular homogenate, spermatozoa, or extracts thereof, in adjuvant, induces aspermatogenesis in the guinea pig1,2. This immunologically induced cellular destructive response is specific in that only the germinal cells are exfoliated. Therefore, immunologically induced aspermatogenesis provides a, model system for investigations of auto-allergic diseases in general. Moreover, the system affords an opportunity to examine problems relating to cell replication as well as the control of cell proliferation. It is important, therefore, to gain knowledge of the essential structure of the antigen(s) inducing aspermatogenesis. This communication provides information regarding the amino-acid content of the antigen(s) and supplements previous reports of other characteristics of this material3,4.

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References

  1. Freund, J., Lipton, M. M., and Thompson, G. E., J. Exp. Med., 97, 711 (1953).

    Article  CAS  Google Scholar 

  2. Katsh, S., Intern. Arch. Allergy App. Immunol., 15, 172 (1959).

    Article  CAS  Google Scholar 

  3. Katsh, S., Intern. Arch. Allergy App. Immunol., 16, 241 (1960).

    Article  CAS  Google Scholar 

  4. Katsh, S., and Katsh, G. F., Fertil. and Steril., 12, 522 (1961).

    Article  CAS  Google Scholar 

  5. Katsh, S., J. Urol., 87, 896 (1962).

    Article  CAS  Google Scholar 

  6. Spackman, D. H., Stein, W. H., and Moore, S., Anal. Chem., 30, 1190 (1958).

    Article  CAS  Google Scholar 

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Author notes

  1. CHARLES H. KIRKPATRICK: Special Program Fellow, U.S. Public Health Service.

Authors and Affiliations

  1. Departments of Medicine and Pharmacology, University of Colorado Medical Center, Denver

    CHARLES H. KIRKPATRICK & SEYMOUR KATSH

Authors
  1. CHARLES H. KIRKPATRICK
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  2. SEYMOUR KATSH
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KIRKPATRICK, C., KATSH, S. Amino-acid Content of Antispermatogenic Antigen. Nature 201, 197–198 (1964). https://doi.org/10.1038/201197a0

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