Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Possible Presence of Lipid Peroxides in Tissues of Tocopherol-deficient Animals

Abstract

THE possible presence of organic peroxide-like substances in animal cells has been considered in relation to the biological function of tocopherol1, the mechanism of action of damaging radiation2, and the swelling of mitochondria in the presence of various agents3,4. In addition to application of these problems, the existence of such peroxides would pose questions related to their in vivo formation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Dam, H., Ann. N.Y. Acad. Sci., 52, 195 (1949).

    Article  ADS  CAS  Google Scholar 

  2. Horgan, V. J., and Philpot, J. St. L., J. Radiol., 27, 63 (1954).

    Article  CAS  Google Scholar 

  3. Neubert, D., Wojtezak, A. B., and Lehninger, A. L., Proc. U.S. Nat. Acad. Sci., 48, 1951 (1962).

    Article  Google Scholar 

  4. Hoffsten, P. E., Hunter, jun., F. E., Gebicki, J. M., and Weinstein, J., Biochem. Biophys. Res. Comm., 7, 276 (1962).

    Article  CAS  Google Scholar 

  5. Dam, H., and Granados, H., Acta Phys. Scand., 10, 162 (1945).

    Article  CAS  Google Scholar 

  6. Tappel, A. L., and Zalkin, H., Arch. Biochem. Biophys., 80, 333 (1959).

    Article  CAS  Google Scholar 

  7. Bieri, J. G., and Anderson, A. A., Arch. Biochem. Biophys., 90, 105 (1960).

    Article  CAS  Google Scholar 

  8. Bernheim, F., Bernheim, M. L. C., and Wilbur, K. M., J. Biol. Chem., 174, 257 (1941).

    Google Scholar 

  9. Dahle, L. K., Hill, E. G., and Holman, R. T., Arch. Biochem. Biophys., 98, 253 (1962).

    Article  CAS  Google Scholar 

  10. Carpenter, M. P., Kitabchi, A. E., McCay, P. B., and Caputto, R., J. Biol. Chem., 234, 2814 (1959).

    CAS  PubMed  Google Scholar 

  11. Caputto, R., McCay, P. B., and Carpenter, M. P., Amer. J. Clin. Nutr., 9, 61 (1961).

    Article  CAS  Google Scholar 

  12. Krishnamurthy, S., and Bieri, J. G., J. Nutr., 77, 245 (1962).

    Article  CAS  Google Scholar 

  13. Farmer, E. H., Koch, H. P., and Sutton, D. A., J. Chem. Soc., 541 (1943).

  14. Horgan, V. J., Philpot, J. St. L., Porter, B. W., and Roodyn, D. B., Biochem. J., 67, 551 (1957).

    Article  CAS  Google Scholar 

  15. Loftus Hills, G., and Thiel, C. C., J. Dairy Res., 14, 340 (1946).

    Article  Google Scholar 

  16. Kitabchi, A. E., McCay, P. B., Carpenter, M. P., Trucco, R. E., and Caputto, R., J. Biol. Chem., 235, 1951 (1960).

    Google Scholar 

  17. Caputto, R., Trucco, R. E., and Kitabchi, A. E., Ann. N.Y. Acad. Sci., 92, 79 (1961).

    Article  ADS  CAS  Google Scholar 

  18. Caputto, R., McCay, P. B., and Carpenter, M. P., J. Biol. Chem., 233, 1025 (1958).

    CAS  PubMed  Google Scholar 

  19. Roe, J. H., and Kuether, C. A., J. Biol. Chem., 147, 399 (1943).

    CAS  Google Scholar 

  20. Burns, J. J., Mosback, E. H., and Schulenberg, S., J. Biol. Chem., 207, 679 (1954).

    CAS  PubMed  Google Scholar 

  21. Sealock, R. R., and Silberstein, H. E., J. Biol. Chem., 135, 251 (1940).

    CAS  Google Scholar 

  22. LaDu, B. N., and Zannoni, V. G., J. Biol. Chem., 217, 777 (1955).

    CAS  Google Scholar 

  23. Horgan, V. J., and Philpot, J. St. L., Intern. J. Rad. Biol., 5, 167 (1952).

    Google Scholar 

  24. McCay, P. B., Kitabchi, A. E., Caputto, R., and Trucco, R. E., Biochem. Biophys. Res. Comm., 4, 469 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

EL-KHATIB, S., CHENAU, U., CARPENTER, M. et al. Possible Presence of Lipid Peroxides in Tissues of Tocopherol-deficient Animals. Nature 201, 188–189 (1964). https://doi.org/10.1038/201188a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/201188a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing