Evidence of Fibrinogenuria in the Nephrotic Syndrome

Abstract

DURING 1959 I had the opportunity of examining in the urine of a case of nephrotic syndrome the development of a large fibrin thrombus, following the addition of thrombin (Fig. 1). This fact was repeatedly affirmed and therefore there was no doubt that the proteinuric urine of the patient Maria A. contained a significant amount of fibrinogen. This observation attracted my interest particularly, because the investigation of fibrinogenuria following the addition of thrombin in urine, after correction for pH (pH 7.0–7.5) at a temperature of 37° C, had been previously tried in 30 cases of nephrotic syndrome during the years 1956–59 and had been always negative⁵.