Abstract
COAGULATION factor V is involved in the production of both extrinsic and intrinsic thromboplastin in the blood. It deteriorates rapidly during blood storage and the one-stage prothrombin time of stored plasma is prolonged because of factor V deficiency. The factor V concentration of test material may be determined by adding dilutions to aged plasma and comparing the degree of shortening of the prothrombin time with that achieved by the addition of varying concentrations of normal plasma.
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PITNEY, W. Assay of Factor V Activity. Nature 201, 1234–1235 (1964). https://doi.org/10.1038/2011234a0
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DOI: https://doi.org/10.1038/2011234a0
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