Abstract
THE biochemical derangements characteristic of the heredofamilial disorders galactossemia, acatalasæmia and glucose-6-phosphate dehydrogenase deficiency have been demonstrated in cell cultures derived from explants of skin obtained by biopsy1–3. Since biochemical alterations may be manifested in tissues remote from the site of primary expression of a disorder, it was reasonable to anticipate that the disturbed metabolism of the neurone in the cerebral sphingolipidoses might be evident in cell strains derived from skin explants in these disorders as well. In this communication we report the results of the examination of neuraminic acid content of different cell strains derived from affected and control subjects.
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References
Krooth, R. S., and Weinberg, A. N., Exp. Cell Res., 25, 585 (1961).
Krooth, R. S., Howell, R. R., and Hamilton, H. R., J. Exp. Med., 115, 313 (1962).
Gartler, S. M., Gandini, E., and Ceppellini, P., Nature, 193, 602 (1962).
Warren, L., J. Biol. Chem., 234, 1971 (1959).
Kimura, A., Exp. Cell Res., 23, 616 (1961).
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EIBEN, R., GARTLER, S. Neuraminic Acid Investigations of Human Cell Strains derived from Explants of Skin in Cell Culture. Nature 201, 1050–1051 (1964). https://doi.org/10.1038/2011050a0
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DOI: https://doi.org/10.1038/2011050a0
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