Abstract
THE electrophoretic pattern of the enzyme lactic dehydrogenase (LDH) is composed of several bands. These bands are believed to be different molecular forms of the enzyme and have been called ‘isozymes’1. It has been suggested that these isozymes result from various tetrameric associations of two sub-units A and B2,3 for which there is some experimental evidence4. The pattern of LDH isozymes is tissue specific5, though the pattern in fœtal tissues is usually different from that found in adult tissues6,7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Markert, C. L., and Møller, F., Proc. U.S. Nat. Acad. Sci., 45, 753 (1959).
Appella, E., and Markert, C. L., Biochem. Biophys. Res. Comm., 6, 171 (1961).
Markert, C. L., Proc. Thirteenth Ann. Conf. Kidney, edit. by Metcoff, J. (Northwestern Univ. Press, Evanston, Ill., 1962).
Markert, C. L., Science, 140, 1329 (1963).
Wróblewski, F., and Gregory, K. F., Ann. N. Y. Acad. Sci., 94, 912 (1961).
Cahn, R. D., Kaplan, N. O., Levine, L., and Zwilling, E., Science, 136, 962 (1962).
Wiggert, B., and Villee, C. A., Science, 138, 509 (1962).
Wieme, R. J., and Van Maercke, Y., Ann. N. Y. Acad. Sci., 94, 898 (1961).
Vesell, E. S., Ann. N. Y. Acad. Sci., 94, 877 (1961).
Richterich, R., Gautier, E., Egli, W., Zuppinger, K., and Rossi, E., Klin. Wschr., 39, 346 (1961).
Lowenthal, A., Van Sande, M., and Karcher, D., Ann. N. Y. Acad. Sci., 94, 988 (1961).
Leyburn, P., Thomson, W. H. S., and Walton, J. N., Ann. Hum. Genet, 25, 41 (1961).
Boyer, S. H., Fainer, D. C., and Naughton, M. A., Science, 40, 1228 (1963).
Smithies, O., Biochem. J., 71, 585 (1959).
Blanco, A., and Zinkham, W. H., Science, 139, 601 (1963).
Wieme, R. J., and Herpol, J. E., Nature, 194, 287 (1962).
Pearson, C. M., Rev. Canad. Biol., 21, 533 (1962).
Emery, A. E. H., Clin. Orthop. (in the press).
Dreyfus, J. C., Démos, J., Schapira, F., and Schapira, G., C.R. Acad. Sci., Paris, 254, 4384 (1962).
Emery, A. E. H., Lancet, i, 1126 (1963).
Chancellor-Maddison, J., and Noll, C. R., Science, 142, 60 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
EMERY, A. Electrophoretic Pattern of Lactic Dehydrogenase in Carriers and Patients with Duchenne Muscular Dystrophy. Nature 201, 1044–1045 (1964). https://doi.org/10.1038/2011044a0
Issue Date:
DOI: https://doi.org/10.1038/2011044a0
This article is cited by
-
Dystrophic mutation (dy2J) affecting regulation of lactate dehydrogenase (LDH) and pyruvate kinase (PK) in C57BL/6J mice
Experientia (1982)
-
Quantitative EMG and histological carrier detection of duchenne muscular dystrophy
Journal of Neurology (1977)
-
Trophic influences of the nervous system: Their biochemical basis and disturbance in skeletal muscle
Neuroscience and Behavioral Physiology (1973)
-
LDH-Isoenzyme im Muskel bei neuromuskul�ren Erkrankungen und bei Konduktorinnen der recessiv X-chromosomalen Muskeldystrophie (Duchenne)
Zeitschrift f�r Kinderheilkunde (1972)
-
Research in Muscular Dystrophy
Nature (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
