Abstract
IN examining iodine metabolism in the rat, the greatest source of error lies in the technique of urine collection. The main obstacle has been contamination of the urine by exogenous iodide from sources such as fæces, foodstuffs, glassware, etc. Many methods have been used in an attempt to overcome this difficulty1–10, but none of them has been wholly successful. Another source of error is loss of urine by evaporation and absorption by fæces. In methods where radioactive iodine is used, another disadvantage lies in the washing5 necessary to avoid loss of radioiodine, with consequent loss of counting efficiency.
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References
Brittain, R. T., Lab. Practice, 8, 279 (1959).
Isler, H., Leblond, C. P., and Axelard, A. A., Endocrinol., 62, 169 (1958).
Kellogg, W. R., and Isselbacher, K., J. Amer. Physiol., 177, 27 (1954).
Lazarow, A., Methods in Medical Research, 6, 216 (The Year Book Pub., Inc., Chicago, 1954).
Albert, A., Endocrinol., 50, 328 (1952).
Guest, G. M., Brodsky, W. A., and Nelson, N., Metabolism, 1, 89 (1962).
Harned, B. K., Cunningham, R. W., and Gill, E. R., Science, 109, 489 (1949).
Rapp, K. I., Skinner, J. T., and McHargue, J. S., J. Lab. and Clin. Med., 31, 598 (1946).
Ackroyd, H., and Hopkins, F. G., Biochem. J., 10, 531 (1961).
Hatai, S., Amer. J. Physiol., 14, 120 (1905).
Reinecke, R. M., Ball, H. A., and Samuels, L. T., Proc. Soc. Exp. Biol. and Med., 41, 44 (1939).
Cororan, A. C., Methods in Medical Research, 5, 246 (The Year Book Pub., Inc., Chicago, 1952).
Zak, B., Anal. Chem., 24, 1345 (1952).
Farrell, M. P., and Richmond, M. H., Clin. Chim. Acta. B.R., 6, 620 (1961).
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ABOUL-KHAIR, S., CROOKS, J. & MACGREGOR, A. A Technique for Urine Collection in the Female Rat for Investigating Iodine Metabolism. Nature 201, 1032–1034 (1964). https://doi.org/10.1038/2011032b0
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DOI: https://doi.org/10.1038/2011032b0
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