Abstract
TETRAPHENYLPORPHINESULPHONATE (TPPS) is a synthetic, non-naturally occurring porphine derivative which accumulates to a greater extent in the tumours than in the other tissues of tumour-bearing rats after parenteral administration1. Because of its optical and solubility properties it can be differentiated from, and analysed in the presence of, endogenous porphyrin. These properties made possible quantitative study of two aspects of the tumour localization of porphyrin that had been seen grossly with other parenterally administered porphyrine : the greater apparent accumulation in the necrotic portions of the tumours2,3, and the absence of apparent red fluorescence in some tissues despite high porphyrin concentrations4.
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WINKELMAN, J., HAYES, J. Distribution of Endogenous and Parenterally Administered Porphyrin in Viable and Necrotic Portions of a Transplantable Tumour. Nature 200, 903–904 (1963). https://doi.org/10.1038/200903b0
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DOI: https://doi.org/10.1038/200903b0
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