Abstract
IT has been found that male skin grafts are rejected by female mice in the C57BL strain1. On the other hand, it has been well ascertained that an introduction of the histocompatibility antigens into inbred mice can elicit humoral antibodies to cause hæmagglutination of the donor red cells. This communication shows that the sera of female mice sensitized with male tissues can agglutinate specifically blood cells of intact male mice. DD strain mice were used for experiments. The female animals were subjected to the following treatment: A subcutaneous injection of 0.2 ml. testis-Freund's adjuvant emulsion per week for 4–6 weeks. Each of the injections contained 15–33 per cent testis homogenate. One to two weeks after the last injection the antisera were collected from the sensitized female mice, and kept at −20° C until the use for the present hæmagglutination test.
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Eichwald, E. J., Silmser, C. R., and Wheeler, H., Ann. N.Y. Acad. Sci., 64, 737 (1957).
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FURUSAWA, M., KOTANI, M. & TAKEUCHI, H. Male Specific Hæmagglutination in Mice. Nature 200, 182 (1963). https://doi.org/10.1038/200182b0
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DOI: https://doi.org/10.1038/200182b0
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