Abstract
IT was found1 some time ago that the toxicities Ct of many physically toxic compounds could be estimated by the equation: where k is a constant equal to 0.012, CB is a measure of the intensity of the toxicity, and P is the parachor, which is used as a measure of molecular volume. Equations similar to (1) have been used successfully for the estimation of partition coefficients2, x, for organic compounds between organic solvents and water and of solubilities2,3 of organic compounds in water. When substances interact with a solvent, for example, by hydrogen bonding with the water, a further term EA is required in the equation so that, for example: This equation (2) was tested2 on figures given by Collander4 for partition coefficients x between isobutanol and water and between ether and water with k equal to 0.012 as before. For simple esters and alcohols EA values were found between − 1 and − 2.
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McGOWAN, J. Partition Coefficients and Biological Activities. Nature 200, 1317 (1963). https://doi.org/10.1038/2001317a0
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DOI: https://doi.org/10.1038/2001317a0
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