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Effect of Nitrogen Mustard on Erythrocyte Acetylcholinesterase

Nature volume 200, pages 1110–1111 (1963)Cite this article

Abstract

NITROGEN mustard (HN2) is known to inactivate certain enzymes, particularly hexokinases and phosphatases1, in addition to the better-known effects on nucleic acids common to all alkylating agents1–5. In the course of examining the effects of nitrogen mustard on circulating erythrocytes, it became important to assay its effect, if any, on erythrocyte acetylcholinesterase. This enzyme is located on the red cell surface, accessible to trypsin inactivation6.

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Author information

Author notes

  1. P. C. VINCENT: British Tobacco Company (Australia) Fellow in Cancer Research.

Authors and Affiliations

  1. Wellcome Laboratories for Experimental Medicine and Surgery, Royal North Shore Hospital of Sydney, Crows Nest, New South Wales

    P. C. VINCENT, NEA BRITTLE & T. S. REEVE

  2. Department of Surgery, University of Sydney,

    P. C. VINCENT, NEA BRITTLE & T. S. REEVE

Authors
  1. P. C. VINCENT
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  2. NEA BRITTLE
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  3. T. S. REEVE
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VINCENT, P., BRITTLE, N. & REEVE, T. Effect of Nitrogen Mustard on Erythrocyte Acetylcholinesterase. Nature 200, 1110–1111 (1963). https://doi.org/10.1038/2001110a0

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