Abstract
IN most considerations of the role of the antigen in antibody formation the assumption is made that a template is either formed or activated. A template, by definition, is a system whereby many replicas are produced. The need for a template is based largely on the secondary response in which large quantities of antibodies are produced in response to small quantities of antigen over a long period of time. This, indeed, does appear to require a template. I wish to question whether the information available indicates that primary antibody formation requires a template.
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Stevens, K. M., J. Immunol., 76, 187 (1956).
Stevens, K. M., J. Hygiene, 55, 489 (1957).
Stevens, K. M., and Pietryk, H. C., Fed. Proc., 18, 599 (1959).
Stevens, K. M., and Riley, P. A., J. Immunol., 76, 181 (1956).
Schmidt, M. H., and Wolfe, H. R., J. Immunol., 71, 214 (1953).
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STEVENS, K. Template Requirement in the Primary Antibody Response. Nature 200, 1017 (1963). https://doi.org/10.1038/2001017a0
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DOI: https://doi.org/10.1038/2001017a0
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