Abstract
PREVIOUS work1 has shown that 4,4′-methylenedianiline causes an increase in the endometrial carbonic anhydrase when administered to rabbits. The mechanism underlying the activating effect of methylenedianiline on the endometrial enzyme is considered to be dependent on the adrenals, presumably due to the release of progestogen arising by a block of adrenal corticosteroidogenesis. Since evidence2–4 concerning antagonisms between œstrogen and progesterone on endometrial carbonic anhydrase has been given, attempts were made to clarify how certain œstrogens affect the response of endometrial carbonic anhydrase to methylenedianiline.
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References
Yamashita, K., Amer. J. Physiol., 205, 195 (1963).
Lutwak-Mann, C., and Adams, C. E., J. Endocrinol., 15, 43 (1957).
Miyake, T., and Pincus, G., Proc. Soc. Exp. Biol. Med., 99, 478 (1958).
Yamashita, K., and Kurouji, K., Proc. Soc. Exp. Biol. Med., 107, 444 (1961).
Clauberg, C., Zent. Gynäkol, 54, 2757 (1930).
Miyake, T., and Pincus, G., Endocrinol., 63, 816 (1958).
Vogt, M., J. Physiol., 130, 601 (1954).
Holzbauer, M., J. Physiol., 139, 294 (1957).
Holzbauer, M., J. Physiol., 139, 306 (1957).
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YAMASHITA, K. Inhibitory Effects of Œstrogens on Augmented Activity of Endometrial Carbonic Anhydrase caused by 4,4′-Methylenedianiline. Nature 200, 81–82 (1963). https://doi.org/10.1038/200081b0
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DOI: https://doi.org/10.1038/200081b0
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