Abstract
EXPERIMENTAL phenylketonuria has been induced in the rhesus monkey by feeding excess dietary phenyl-alanine1,2. The phenylalanine plasma level was markedly elevated, and the urinary excretion of phenylketones and phenylacetyl glutamine were comparable with that found in children with phenylketonuria. Behavioural and learning tests have demonstrated a severe degree of mental retardation in these experimental animals. This report provides data on the excretion of 5-hydroxyindolyl-acetic acid and indolyl-3-acids in these monkeys and demonstrates that the role of tryptophan is similar in both the experimental disease and in phenylketonuric infants.
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BOGGS, D., MCLAY, D., KAPPY, M. et al. Excretion of Indolyl Acids in Phenylketonuric Monkeys. Nature 200, 76 (1963). https://doi.org/10.1038/200076a0
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DOI: https://doi.org/10.1038/200076a0
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